Results


1.) Similarity ranking (gene sets vs. pathways)
2.) Regression plot: XD-score vs. Significance of overlap
3.) Download gene set similarity ranking table
4.) Download matrix of tissue-specific Xd-scores






1) Similarity ranking (gene set vs. pathways/processes)



Please click on the column titles to sort table entries:

Annotation (pathway/process)  sortSignificance of network distance distribution (XD-Score)  sort Significance of overlap (Fisher-test, q-value)  sort Dataset size (uploaded gene set)  sortDataset size (pathway gene set)  sortDataset size (overlap)  sort Tissue-specific XD-scores  sort
hsa05216:Thyroid cancer
see mapped genes
0.882663.0e-113382916 (show)
tissue specificity
hsa05213:Endometrial cancer
see mapped genes
0.612474.1e-113385119 (show)
tissue specificity
hsa04320:Dorso-ventral axis formation
see mapped genes
0.603352.4e-063382510 (show)
tissue specificity
hsa05219:Bladder cancer
see mapped genes
0.591631.8e-093384316 (show)
tissue specificity
hsa05218:Melanoma
see mapped genes
0.588525.4e-143387025 (show)
tissue specificity
hsa05214:Glioma
see mapped genes
0.536162.8e-113386421 (show)
tissue specificity
hsa05220:Chronic myeloid leukemia
see mapped genes
0.532691.7e-133387625 (show)
tissue specificity
hsa05221:Acute myeloid leukemia
see mapped genes
0.532579.5e-103385618 (show)
tissue specificity
hsa05215:Prostate cancer
see mapped genes
0.522941.5e-143388728 (show)
tissue specificity
hsa05223:Non-small cell lung cancer
see mapped genes
0.504365.8e-093385617 (show)
tissue specificity
hsa05211:Renal cell carcinoma
see mapped genes
0.418756.0e-083386817 (show)
tissue specificity
hsa05210:Colorectal cancer
see mapped genes
0.417212.9e-103388622 (show)
tissue specificity
hsa00720:Reductive carboxylate cycle (CO2 fixation)
see mapped genes
0.412685.3e-02338113 (show)
tissue specificity
hsa05212:Pancreatic cancer
see mapped genes
0.405286.1e-093387519 (show)
tissue specificity
hsa04115:p53 signaling pathway
see mapped genes
0.371893.2e-063386214 (show)
tissue specificity
hsa00020:Citrate cycle (TCA cycle)
see mapped genes
0.369264.7e-03338266 (show)
tissue specificity
hsa04662:B cell receptor signaling pathway
see mapped genes
0.356711.2e-053386013 (show)
tissue specificity
hsa04012:ErbB signaling pathway
see mapped genes
0.344952.7e-073388818 (show)
tissue specificity
hsa04660:T cell receptor signaling pathway
see mapped genes
0.325084.6e-073389218 (show)
tissue specificity
hsa05040:Huntington's disease
see mapped genes
0.274953.2e-02338295 (show)
tissue specificity
hsa04150:mTOR signaling pathway
see mapped genes
0.246164.8e-03338498 (show)
tissue specificity
hsa05222:Small cell lung cancer
see mapped genes
0.241391.1e-043388814 (show)
tissue specificity
hsa04110:Cell cycle
see mapped genes
0.227002.1e-0433810815 (show)
tissue specificity
hsa04664:Fc epsilon RI signaling pathway
see mapped genes
0.226274.1e-033387310 (show)
tissue specificity
hsa04630:Jak-STAT signaling pathway
see mapped genes
0.215182.3e-0733814623 (show)
tissue specificity
hsa04520:Adherens junction
see mapped genes
0.212234.1e-033387310 (show)
tissue specificity
hsa04916:Melanogenesis
see mapped genes
0.211311.2e-0333810013 (show)
tissue specificity
hsa04210:Apoptosis
see mapped genes
0.207273.0e-033388311 (show)
tissue specificity
hsa04370:VEGF signaling pathway
see mapped genes
0.195153.2e-02338708 (show)
tissue specificity
hsa04720:Long-term potentiation
see mapped genes
0.188342.6e-02338678 (show)
tissue specificity
hsa04330:Notch signaling pathway
see mapped genes
0.182281.2e-01338445 (show)
tissue specificity
hsa01510:Neurodegenerative Diseases
see mapped genes
0.166212.4e-01338384 (show)
tissue specificity
hsa05030:Amyotrophic lateral sclerosis (ALS)
see mapped genes
0.160825.1e-01338182 (show)
tissue specificity
hsa05217:Basal cell carcinoma
see mapped genes
0.158492.3e-01338545 (show)
tissue specificity
hsa04510:Focal adhesion
see mapped genes
0.152311.9e-0533819623 (show)
tissue specificity
hsa04920:Adipocytokine signaling pathway
see mapped genes
0.146123.5e-02338728 (show)
tissue specificity
hsa04910:Insulin signaling pathway
see mapped genes
0.143006.6e-0433813616 (show)
tissue specificity
hsa04710:Circadian rhythm
see mapped genes
0.142761.0e+00338121 (show)
tissue specificity
hsa04912:GnRH signaling pathway
see mapped genes
0.113881.4e-01338978 (show)
tissue specificity
hsa04810:Regulation of actin cytoskeleton
see mapped genes
0.113102.0e-0333820319 (show)
tissue specificity
hsa04010:MAPK signaling pathway
see mapped genes
0.085681.7e-0333825222 (show)
tissue specificity
hsa04120:Ubiquitin mediated proteolysis
see mapped genes
0.082662.1e-0233811111 (show)
tissue specificity
hsa04310:Wnt signaling pathway
see mapped genes
0.079873.7e-013381469 (show)
tissue specificity
hsa04730:Long-term depression
see mapped genes
0.074751.1e-01338747 (show)
tissue specificity
hsa04930:Type II diabetes mellitus
see mapped genes
0.067767.3e-01338443 (show)
tissue specificity
hsa04540:Gap junction
see mapped genes
0.064381.6e-023389010 (show)
tissue specificity
hsa04650:Natural killer cell mediated cytotoxicity
see mapped genes
0.063834.4e-0233812611 (show)
tissue specificity
hsa04350:TGF-beta signaling pathway
see mapped genes
0.048571.0e+00338854 (show)
tissue specificity
hsa04530:Tight junction
see mapped genes
0.045774.5e-0233812711 (show)
tissue specificity
hsa04670:Leukocyte transendothelial migration
see mapped genes
0.043514.6e-013381137 (show)
tissue specificity
hsa04340:Hedgehog signaling pathway
see mapped genes
0.042311.0e+00338552 (show)
tissue specificity
hsa05120:Epithelial cell signaling in Helicobacter pylori infection
see mapped genes
0.023913.2e-01338615 (show)
tissue specificity
hsa04640:Hematopoietic cell lineage
see mapped genes
0.019971.0e+00338913 (show)
tissue specificity
hsa05130:Pathogenic Escherichia coli infection - EHEC
see mapped genes
0.017633.8e-01338474 (show)
tissue specificity
hsa05131:Pathogenic Escherichia coli infection - EPEC
see mapped genes
0.017633.8e-01338474 (show)
tissue specificity
hsa05060:Prion disease
see mapped genes
0.004841.0e+00338131 (show)
tissue specificity
hsa04620:Toll-like receptor signaling pathway
see mapped genes
0.003775.0e-01338956 (show)
tissue specificity
hsa00592:alpha-Linolenic acid metabolism
see mapped genes
-0.000981.0e+00338140
tissue specificity
hsa03050:Proteasome
see mapped genes
-0.000981.0e+00338210
tissue specificity
hsa05050:Dentatorubropallidoluysian atrophy (DRPLA)
see mapped genes
-0.000981.0e+00338140
tissue specificity
hsa04060:Cytokine-cytokine receptor interaction
see mapped genes
-0.020462.6e-0133824014 (show)
tissue specificity
hsa00534:Heparan sulfate biosynthesis
see mapped genes
-0.029994.1e-01338152 (show)
tissue specificity
hsa00562:Inositol phosphate metabolism
see mapped genes
-0.037501.0e+00338432 (show)
tissue specificity
hsa04020:Calcium signaling pathway
see mapped genes
-0.041601.0e+003381726 (show)
tissue specificity
hsa04070:Phosphatidylinositol signaling system
see mapped genes
-0.047691.0e+00338693 (show)
tissue specificity
hsa04950:Maturity onset diabetes of the young
see mapped genes
-0.048171.0e+00338240
tissue specificity
hsa04360:Axon guidance
see mapped genes
-0.048735.6e-013381227 (show)
tissue specificity
hsa03022:Basal transcription factors
see mapped genes
-0.059761.0e+00338290
tissue specificity
hsa03320:PPAR signaling pathway
see mapped genes
-0.065461.0e+00338692 (show)
tissue specificity
hsa00240:Pyrimidine metabolism
see mapped genes
-0.096151.0e+00338781 (show)
tissue specificity
hsa00565:Ether lipid metabolism
see mapped genes
-0.098641.0e+00338291 (show)
tissue specificity
hsa00230:Purine metabolism
see mapped genes
-0.101601.0e+003381363 (show)
tissue specificity
hsa04512:ECM-receptor interaction
see mapped genes
-0.105851.0e+00338821 (show)
tissue specificity
hsa00670:One carbon pool by folate
see mapped genes
-0.106571.0e+00338161 (show)
tissue specificity
hsa03030:DNA polymerase
see mapped genes
-0.121501.0e+00338240
tissue specificity
hsa03020:RNA polymerase
see mapped genes
-0.122811.0e+00338190
tissue specificity
hsa05010:Alzheimer's disease
see mapped genes
-0.125071.0e+00338280
tissue specificity
hsa04514:Cell adhesion molecules (CAMs)
see mapped genes
-0.129951.0e+003381331 (show)
tissue specificity
hsa03010:Ribosome
see mapped genes
-0.137181.0e+00338640
tissue specificity
hsa04614:Renin-angiotensin system
see mapped genes
-0.137731.0e+00338170
tissue specificity
hsa05110:Cholera - Infection
see mapped genes
-0.163051.0e+00338361 (show)
tissue specificity
hsa04940:Type I diabetes mellitus
see mapped genes
-0.166811.0e+00338482 (show)
tissue specificity
hsa00271:Methionine metabolism
see mapped genes
-0.168501.0e+00338140
tissue specificity
hsa00710:Carbon fixation
see mapped genes
-0.168501.0e+00338210
tissue specificity
hsa05020:Parkinson's disease
see mapped genes
-0.168501.0e+00338210
tissue specificity
hsa04612:Antigen processing and presentation
see mapped genes
-0.168611.0e+00338792 (show)
tissue specificity
hsa00790:Folate biosynthesis
see mapped genes
-0.168741.0e+00338372 (show)
tissue specificity
hsa00680:Methane metabolism
see mapped genes
-0.177321.0e+00338100
tissue specificity
hsa00272:Cysteine metabolism
see mapped genes
-0.184801.0e+00338171 (show)
tissue specificity
hsa00252:Alanine and aspartate metabolism
see mapped genes
-0.206111.0e+00338260
tissue specificity
hsa04740:Olfactory transduction
see mapped genes
-0.211581.0e+00338310
tissue specificity
hsa00960:Alkaloid biosynthesis II
see mapped genes
-0.212791.0e+00338141 (show)
tissue specificity
hsa00251:Glutamate metabolism
see mapped genes
-0.212911.0e+00338281 (show)
tissue specificity
hsa00903:Limonene and pinene degradation
see mapped genes
-0.214731.0e+00338251 (show)
tissue specificity
hsa00310:Lysine degradation
see mapped genes
-0.220881.0e+00338461 (show)
tissue specificity
hsa00500:Starch and sucrose metabolism
see mapped genes
-0.221021.0e+00338642 (show)
tissue specificity
hsa00640:Propanoate metabolism
see mapped genes
-0.224341.0e+00338320
tissue specificity
hsa04080:Neuroactive ligand-receptor interaction
see mapped genes
-0.225831.0e+003382501 (show)
tissue specificity
hsa00190:Oxidative phosphorylation
see mapped genes
-0.229961.0e+003381064 (show)
tissue specificity
hsa00030:Pentose phosphate pathway
see mapped genes
-0.240291.0e+00338250
tissue specificity
hsa00521:Streptomycin biosynthesis
see mapped genes
-0.240291.0e+00338100
tissue specificity
hsa00620:Pyruvate metabolism
see mapped genes
-0.249701.0e+00338410
tissue specificity
hsa00630:Glyoxylate and dicarboxylate metabolism
see mapped genes
-0.251011.0e+00338120
tissue specificity
hsa00561:Glycerolipid metabolism
see mapped genes
-0.254591.0e+00338450
tissue specificity
hsa00564:Glycerophospholipid metabolism
see mapped genes
-0.257391.0e+00338611 (show)
tissue specificity
hsa00860:Porphyrin and chlorophyll metabolism
see mapped genes
-0.261791.0e+00338300
tissue specificity
hsa00360:Phenylalanine metabolism
see mapped genes
-0.266761.0e+00338251 (show)
tissue specificity
hsa00626:Naphthalene and anthracene degradation
see mapped genes
-0.269011.0e+00338180
tissue specificity
hsa00010:Glycolysis / Gluconeogenesis
see mapped genes
-0.272631.0e+00338600
tissue specificity
hsa00591:Linoleic acid metabolism
see mapped genes
-0.273681.0e+00338310
tissue specificity
hsa00632:Benzoate degradation via CoA ligation
see mapped genes
-0.278931.0e+00338241 (show)
tissue specificity
hsa00910:Nitrogen metabolism
see mapped genes
-0.280041.0e+00338210
tissue specificity
hsa01430:Cell Communication
see mapped genes
-0.283431.0e+003381231 (show)
tissue specificity
hsa00361:gamma-Hexachlorocyclohexane degradation
see mapped genes
-0.289801.0e+00338210
tissue specificity
hsa00590:Arachidonic acid metabolism
see mapped genes
-0.290581.0e+00338510
tissue specificity
hsa00624:1- and 2-Methylnaphthalene degradation
see mapped genes
-0.290991.0e+00338211 (show)
tissue specificity
hsa00071:Fatty acid metabolism
see mapped genes
-0.291721.0e+00338461 (show)
tissue specificity
hsa00220:Urea cycle and metabolism of amino groups
see mapped genes
-0.294141.0e+00338290
tissue specificity
hsa04610:Complement and coagulation cascades
see mapped genes
-0.296091.0e+00338700
tissue specificity
hsa00052:Galactose metabolism
see mapped genes
-0.305561.0e+00338320
tissue specificity
hsa00603:Glycosphingolipid biosynthesis - globoseries
see mapped genes
-0.305561.0e+00338140
tissue specificity
hsa00760:Nicotinate and nicotinamide metabolism
see mapped genes
-0.305561.0e+00338240
tissue specificity
hsa01040:Polyunsaturated fatty acid biosynthesis
see mapped genes
-0.305561.0e+00338120
tissue specificity
hsa04140:Regulation of autophagy
see mapped genes
-0.305561.0e+00338220
tissue specificity
hsa00350:Tyrosine metabolism
see mapped genes
-0.312461.0e+00338531 (show)
tissue specificity
hsa00410:beta-Alanine metabolism
see mapped genes
-0.320061.0e+00338230
tissue specificity
hsa00380:Tryptophan metabolism
see mapped genes
-0.323771.0e+00338550
tissue specificity
hsa00140:C21-Steroid hormone metabolism
see mapped genes
-0.325161.0e+00338120
tissue specificity
hsa00330:Arginine and proline metabolism
see mapped genes
-0.326441.0e+00338320
tissue specificity
hsa04130:SNARE interactions in vesicular transport
see mapped genes
-0.326441.0e+00338320
tissue specificity
hsa04742:Taste transduction
see mapped genes
-0.328591.0e+00338461 (show)
tissue specificity
hsa00040:Pentose and glucuronate interconversions
see mapped genes
-0.353651.0e+00338140
tissue specificity
hsa00280:Valine, leucine and isoleucine degradation
see mapped genes
-0.353651.0e+00338420
tissue specificity
hsa00480:Glutathione metabolism
see mapped genes
-0.355101.0e+00338342 (show)
tissue specificity
hsa00970:Aminoacyl-tRNA biosynthesis
see mapped genes
-0.361611.0e+00338311 (show)
tissue specificity
hsa00600:Sphingolipid metabolism
see mapped genes
-0.361791.0e+00338360
tissue specificity
hsa00051:Fructose and mannose metabolism
see mapped genes
-0.363181.0e+00338410
tissue specificity
hsa00510:N-Glycan biosynthesis
see mapped genes
-0.368331.0e+00338341 (show)
tissue specificity
hsa00440:Aminophosphonate metabolism
see mapped genes
-0.373241.0e+00338150
tissue specificity
hsa00512:O-Glycan biosynthesis
see mapped genes
-0.373241.0e+00338250
tissue specificity
hsa02010:ABC transporters - General
see mapped genes
-0.378961.0e+00338390
tissue specificity
hsa00650:Butanoate metabolism
see mapped genes
-0.379481.0e+00338400
tissue specificity
hsa01030:Glycan structures - biosynthesis 1
see mapped genes
-0.379791.0e+00338993 (show)
tissue specificity
hsa00531:Glycosaminoglycan degradation
see mapped genes
-0.379801.0e+00338170
tissue specificity
hsa00150:Androgen and estrogen metabolism
see mapped genes
-0.388631.0e+00338450
tissue specificity
hsa00100:Biosynthesis of steroids
see mapped genes
-0.390561.0e+00338240
tissue specificity
hsa00363:Bisphenol A degradation
see mapped genes
-0.403021.0e+00338140
tissue specificity
hsa00260:Glycine, serine and threonine metabolism
see mapped genes
-0.408851.0e+00338430
tissue specificity
hsa00340:Histidine metabolism
see mapped genes
-0.414071.0e+00338370
tissue specificity
hsa00604:Glycosphingolipid biosynthesis - ganglioseries
see mapped genes
-0.419771.0e+00338150
tissue specificity
hsa00740:Riboflavin metabolism
see mapped genes
-0.419771.0e+00338150
tissue specificity
hsa00930:Caprolactam degradation
see mapped genes
-0.419771.0e+00338150
tissue specificity
hsa00120:Bile acid biosynthesis
see mapped genes
-0.426151.0e+00338370
tissue specificity
hsa00602:Glycosphingolipid biosynthesis - neo-lactoseries
see mapped genes
-0.432211.0e+00338190
tissue specificity
hsa00450:Selenoamino acid metabolism
see mapped genes
-0.439811.0e+00338250
tissue specificity
hsa00062:Fatty acid elongation in mitochondria
see mapped genes
-0.443481.0e+00338100
tissue specificity
hsa00641:3-Chloroacrylic acid degradation
see mapped genes
-0.453731.0e+00338140
tissue specificity
hsa00530:Aminosugars metabolism
see mapped genes
-0.465631.0e+00338260
tissue specificity
hsa00980:Metabolism of xenobiotics by cytochrome P450
see mapped genes
-0.472861.0e+00338540
tissue specificity
hsa01032:Glycan structures - degradation
see mapped genes
-0.497051.0e+00338320
tissue specificity
hsa00532:Chondroitin sulfate biosynthesis
see mapped genes
-0.516421.0e+00338200
tissue specificity
hsa01031:Glycan structures - biosynthesis 2
see mapped genes
-0.527691.0e+00338520
tissue specificity
hsa00511:N-Glycan degradation
see mapped genes
-0.551261.0e+00338170
tissue specificity
hsa00920:Sulfur metabolism
see mapped genes
-0.559371.0e+00338140
tissue specificity
hsa00533:Keratan sulfate biosynthesis
see mapped genes
-0.572991.0e+00338160
tissue specificity
hsa00770:Pantothenate and CoA biosynthesis
see mapped genes
-0.592021.0e+00338160
tissue specificity
hsa00130:Ubiquinone biosynthesis
see mapped genes
-0.627761.0e+00338110
tissue specificity
hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
see mapped genes
-0.634421.0e+00338130
tissue specificity




2) Regression plot: XD-score vs. Significance of overlap (Fisher test, q-value)

Absolute Pearson correlation between XD-scores and Fisher q-values: 0.84
XD-score significance threshold:
(reqression fit equivalent to Fisher q-value of 0.05
+ upper bound of 95% confidence interval for linear fitting)
0.33